Factor H (30C-CP2038U)
Purified native Human Factor H
Overview
Overview
| Synonyms | Complement Factor H |
|---|---|
| Species | Human |
| Protein Type | Native |
| Applications | User optimized |
Specifications
| Source | Human serum/plasma |
|---|---|
| Molecular Weight | 155 kDa |
| Form & Buffer | Frozen liquid in 10mM sodium phosphate, 145mM NaCl, pH 7.3. |
Storage & Safety
| Storage | Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles. |
|---|---|
| Biohazard Information | Donor samples were tested and found to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. |
General Information
| Biological Significance | Complement factor H (fH) is an essential regulatory component of the alternative pathway of complement. It is critical for prevention of complement activation on host cells and tissues, especially the kidney. It has two functional activities: 1) it controls the formation and decay of the alternative pathway C3/C5 convertase (decay accelerating activity) and 2) it acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor H (cofactor activity). |
|---|
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