Factor VII antibody (70R-12565)
Affinity purified Rabbit polyclonal Factor VII antibody
Overview
Overview
| Synonyms | Polyclonal Factor VII antibody, Anti-Factor VII antibody, coagulation factor VII antibody, eptacog alfa antibody, FVII coagulation protein antibody, serum prothrombin conversion accelerator antibody, F7 antibody, proconvertin antibody, SPCA antibody |
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| Cross Reactivity | Human, Mouse |
| Applications | IHC-P, WB |
| Immunogen | Factor VII antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 209 and 466 of Factor VII |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | Factor VII antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 52 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 0.74 mg/ml |
Usage & Assay Information
| Usage Recommendations | IHC-P: 1:100-1:500, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. |
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