Polyclonal FAN antibody, Anti-FAN antibody, factor associated with N-SMase activation antibody, factor associated with neutral sphingomyelinase activation antibody, NSMAF antibody, FAN antibody, protein FAN antibody
Cross Reactivity
Human
Applications
IHC-P, WB
Immunogen
FAN antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 262 and 570 of FAN
Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
General Information
Biological Significance
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation.