FGF21 protein (30R-AF039)
Purified recombinant Human FGF21 protein
Overview
Overview
| Synonyms | FGFL protein, FGF 21, FGF-21, FGF21, FGF-21 protein, Fibroblast Growth Factor-21 protein, FGF 21 protein, FGF-21 protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of FGF21 protein corresponding to amino acids MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS. |
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| Expression System | E.coli |
| Grade & Purity | > 90% pure |
| Molecular Weight | 19.5 kDa |
| Form & Buffer | Supplied as a lyophilized powder. |
Usage & Assay Information
| Bioactivity | Determined by dose-dependent ability to reduce tetrazolium salt, WST-8, by dehydrogenase activitiesof BaF3 cells expressing FGF receptors using Cell Counting Kit-8 (CCK-8). |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | FGF21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes. |
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