Fibronectin antibody (10R-8425)
Mouse monoclonal Fibronectin antibody
Overview
Overview
| Synonyms | Monoclonal Fibronectin antibody, Anti-Fibronectin antibody, FN1 antibody, fibronectin 1 antibody, BOS_2065 antibody, cig antibody, cold-insoluble globulin antibody, cumulus cell-specific fibronectin 1 transcript antibody, E330027I09 antibody, ED-B antibody, embryo-specific fibronectin 1 transcript antibody, fb80d10 antibody, FIBNEC antibody, fibronectin antibody, fibronectin-1 antibody, fibronectin ED-A- region antibody, fibronectin variable region antibody, FINC antibody, FN antibody, Fn-1 antibody, fn1l antibody, fn2 antibody, FNZ antibody, gene C antibody, GFND antibody, GFND2 antibody, LETS antibody, migration-stimulating factor antibody, MSF antibody, nat antibody, natter antibody, PANDA_001577 antibody |
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| Cross Reactivity | Human |
| Applications | IP, WB |
| Immunogen | Fibronectin antibody was raised in Mouse using Fibronectin protein purified from Human plasma as the immunogen |
Specifications
| Host | Mouse |
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| Clone | 23C9 |
| Isotype | IgG2b kappa |
| Method of Purification | Fibronectin antibody was purified by ammonium sulfate precipitation |
| Form & Buffer | Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
Usage & Assay Information
| Usage Recommendations | WB: 1:2000, IP: 2 ul |
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Storage & Safety
| Storage | Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles |
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General Information
| Biological Significance | Fibronectin (FN) exists in two main forms: 1) as a soluble glycoprotein in blood plasma (plasma FN), and 2) as an insoluble glycoprotein in tissue extracellular matrices (cellular FN). Many different cell types synthesize fibronectin and secrete it as a disulfide-bonded dimer composed of 230?270 kDa subunits. FN is one of the largest multi-domain proteins that interact with a variety of macromolecules like heparin, collagen /gelatin, and fibrin. FN is involved in many cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/ adhesion and so can be used as a therapeutic agent for wound healing. In addition, its age-dependent increase in plasma and tissues may be accompanied in pathological states, especially in tumor growth, by its proteolytic breakdown. |
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