Follicular Dendritic Cells antibody (10R-6696)

Mouse monoclonal Follicular Dendritic Cells antibody

Synonyms Monoclonal Follicular Dendritic Cells antibody, Anti-Follicular Dendritic Cells antibody, Follicular dentritic cell antibody
Specificity Human
Applications Functional Assay
Assay Information The bioactivity of this protein was determined by transmigration assay of human monocytes. Maximum chemotaxis is observed at less than or equal to 100 ng/ml.

Specifications

Host Mouse
Clone CNA.42
Isotype IgM
Method of Purification Follicular Dendritic Cells antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance The monoclonal antibody CNA.42 recognizes a unique carbohydrate epitope found on follicular dendritic cells from a variety of species. FDCs are large cells in germinal centers of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21, CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis. Staining with this CNA.42 monoclonal antibody is mainly restricted to the plasma membrane but in limited cases may also be cytoplasmic. This monoclonal has been shown to be a useful reagent for both flow cytometry and IHC analysis.

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Price From: Price: €114.52
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