Follicular Dendritic Cells antibody (10R-6696)
Mouse monoclonal Follicular Dendritic Cells antibody
Overview
Overview
| Synonyms | Monoclonal Follicular Dendritic Cells antibody, Anti-Follicular Dendritic Cells antibody, Follicular dentritic cell antibody |
|---|---|
| Specificity | Human |
| Applications | Functional Assay |
| Assay Information | The bioactivity of this protein was determined by transmigration assay of human monocytes. Maximum chemotaxis is observed at less than or equal to 100 ng/ml. |
Specifications
| Host | Mouse |
|---|---|
| Clone | CNA.42 |
| Isotype | IgM |
| Method of Purification | Follicular Dendritic Cells antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer. |
Storage & Safety
| Storage | Store at 2-8 deg C. Do not freeze. Protect from light. |
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General Information
| Biological Significance | The monoclonal antibody CNA.42 recognizes a unique carbohydrate epitope found on follicular dendritic cells from a variety of species. FDCs are large cells in germinal centers of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21, CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis. Staining with this CNA.42 monoclonal antibody is mainly restricted to the plasma membrane but in limited cases may also be cytoplasmic. This monoclonal has been shown to be a useful reagent for both flow cytometry and IHC analysis. |
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