FUBP1 antibody (10R-11446)
Mouse Monoclonal FUBP1 antibody
Overview
Overview
| Synonyms | Monoclonal FUBP1 antibody, Anti-FUBP1 antibody, Far upstream element (FuSE) binding protein 1 antibody, FBP antibody, FuBP |
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| Applications | ELISA, ICC, WB |
| Immunogen | FUBP1 antibody was raised in Mouse using recombinant human FUBP1 (279-448aa) purified from E.coli |
Specifications
| Host | Mouse |
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| Clone | AT14F5 |
| Isotype | IgG2b kappa |
| Method of Purification | FUBP1 antibody was purified by protein A affinity chromatography |
| Form & Buffer | Supplied in liquid form in Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Concentration | 1 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage or -20 deg C for long term storage |
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General Information
| Biological Significance | FUBP1 is a transcriptional regulator and fulfills an important function in the precise control of c-myc transcription. The c-Myc protein is a transcription factor which regulates the transcription of many different target genes that play a role in proliferation, cell cycle progression, differentiation, apoptosis and cell metabolism. Consequently, FUBP1 is also involved in the regulation of proliferation and differentiation, as confirmed by different experimental approaches. Knockdown of FUBP1 or expression of a dominant-negative FUBP1 (DNA-binding domain lacking effector activity) led to proliferation arrest in U2OS and Saos-2 osteosarcoma cells due to reduced c-myc expression. |
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