GADD153 antibody (70R-11813)
Rabbit polyclonal GADD153 antibody
Overview
Overview
| Synonyms | Polyclonal GADD153 antibody, anti-GADD153 antibody, GADD-153 antibody, GADD-153, GADD153, GADD153 antibody, GADD 153 antibody, CEBPZ antibody, CHOP10 antibody, MGC4154 antibody, GADD 153, CHOP antibody, 126337 antibody, P35638 antibody, DDIT3 antibody |
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| Cross Reactivity | Human, Mouse, Rat |
| Applications | IHC, IP, WB |
| Immunogen | GADD153 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 124 of human GADD153 as the immunogen. |
| Assay Information | GADD153 Blocking Peptide, catalog no. 33R-10755, is also available for use as a blocking control in assays to test for specificity of this GADD153 antibody |
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | GADD153 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in PBS buffer containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal |
| Concentration | 200 ug/ml |
Usage & Assay Information
| Usage Recommendations | IP: 10-20 ug/ml, IHC: 10-20 ug/ml, WB: 0.5-4 ug/ml |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | GADD153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. Expression of GADD153 is induced by a variety of cellular stresses, including nutrient deprivation and metabolic perturbations. GADD153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD153 dimers away from “classical” C/EBP binding sites. Thus GADD153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells. |
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