GADD153 antibody (70R-11813)

Rabbit polyclonal GADD153 antibody

Synonyms Polyclonal GADD153 antibody, anti-GADD153 antibody, GADD-153 antibody, GADD-153, GADD153, GADD153 antibody, GADD 153 antibody, CEBPZ antibody, CHOP10 antibody, MGC4154 antibody, GADD 153, CHOP antibody, 126337 antibody, P35638 antibody, DDIT3 antibody
Cross Reactivity Human, Mouse, Rat
Applications IHC, IP, WB
Immunogen GADD153 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 124 of human GADD153 as the immunogen.
Assay Information GADD153 Blocking Peptide, catalog no. 33R-10755, is also available for use as a blocking control in assays to test for specificity of this GADD153 antibody

Specifications

Host Rabbit
Isotype IgG
Method of Purification GADD153 antibody was purified by affinity chromatography
Form & Buffer Supplied in PBS buffer containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal
Concentration 200 ug/ml

Usage & Assay Information

Usage Recommendations IP: 10-20 ug/ml, IHC: 10-20 ug/ml, WB: 0.5-4 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance GADD153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. Expression of GADD153 is induced by a variety of cellular stresses, including nutrient deprivation and metabolic perturbations. GADD153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD153 dimers away from “classical” C/EBP binding sites. Thus GADD153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells.

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