Galactocerebrosidase protein (80R-4346)

Recombinant Human Galactocerebrosidase protein

Synonyms GALC protein, Human Galactocerebrosidase protein, Recombinant GALC, GALCERase protein, EC 3.2.1.46, Galactocerebroside beta-galactosidase, Galactosylceramidase protein, Galactosylceramide beta galactosidase
Species Human
Protein Type Recombinant

Specifications

Residues Full length mature protein, with N terminus His tag. Amino acids 43 - 685: YVLDDSDG LGREFDGIGA VSGGGATSRL LVNYPEPYRS QILDYLFKPN FGASLHILKV EIGGDGQTTD GTEPSHMHYA LDENYFRGYE WWLMKEAKKR NPNITLIGLP WSFPGWLGKG FDWPYVNLQL TAYYVVTWIV GAKRYHDLDI DYIGIWNERS YNANYIKILR KMLNYQGLQR VKIIASDNLW ESISASMLLD AELFKVVDVI GAHYPGTHSA KDAKLTGKKL WSSEDFSTLN SDMGAGCWGR ILNQNYINGY MTSTIAWNLV ASYYEQLPYG RCGLMTAQEP WSGHYVVESP VWVSAHTTQF TQPGWYYLKT VGHLEKGGSY VALTDGLGNL TIIIETMSHK HSKCIRPFLP YFNVSQQFAT FVLKGSFSEI PELQVWYTKL GKTSERFLFK QLDSLWLLDS DGSFTLSLHE DELFTLTTLT TGRKGSYPLP PKSQPFPSTY KDDFNVDYPF FSEAPNFADQ TGVFEYFTNI EDPGEHHFTL RQVLNQRPIT WAADASNTIS IIGDYNWTNL TIKCDVYIET PDTGGVFIAG RVNKGGILIR SARGIFFWIF ANGSYRVTGD LAGWIIYALG RVEVTAKKWY TLTLTIKGHF ASGMLNDKSL WTDIPVNFPK NGWAAIGTHS FEFAQFDNFL VEATR
Expression System E.coli
Grade & Purity > 90% pure
Tag/Conjugate His tag
Form & Buffer Supplied asa liquid inTris-based buffer with 50% glycerol

Storage & Safety

Storage Store at - 20 deg C in small aliquots. Avoid repeated freeze thaw cycles.

General Information

Biological Significance The GALC gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride.
Implications in Disease Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy.
Sequence Information Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Database Links Uniprot: P54803

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Availability: In stock

Price: €166.87
Size: 50 ug
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