GCLC antibody (70R-14031)
Affinity purified Rabbit polyclonal GCLC antibody
Overview
Overview
| Synonyms | Polyclonal GCLC antibody, Anti-GCLC antibody, GLCLC antibody, Glutamate-Cysteine Ligase Catalytic Subunit antibody, GCS antibody, GLCL antibody |
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| Applications | IHC-P, WB |
| Immunogen | GCLC antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human GCS/GCLC, different from the related rat and Rabbit sequences by one amino acid, as the immunogen |
Images
Western Blot analysis using GCLC antibody (70R-14031)
Lane 1: Rat Brain Tissue Lysate; Lane 2: Rat Kidney Tissue Lysate; Lane 3: Rat Heart Tissue Lysate; Lane 1: Rat Lung Tissue Lysate
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | GCLC antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in lyophilized form |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. GCLC is the catalytic subunit of 637 amino acids with a calculated molecular weight of 72.773 kDa. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. |
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