GDF11 protein (30R-AG006)

Purified recombinant Human/Mouse/Rat GDF11 protein

Synonyms BMP-11 protein, GDF 11 protein, GDF-11 protein, GDF-11 protein, GDF-11, Growth/Differentiation Factor-11 protein, GDF11, GDF 11, Human GDF11, Mouse GDF11, Rat GDF11
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Residues Region of GDF11 protein corresponding to amino acids NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS.
Expression System E.coli
Grade & Purity > 98% pure
Molecular Weight 25 kDa
Form & Buffer Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Keep pH below 5.0.

Usage & Assay Information

Bioactivity Activitywas determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 cells. TheED50 for this effect is 8-10 ng/ml

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same.
Sequence Information Complete identity between mature sequences amongst Human, Mouse and Rat species for GDF11

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Availability: In stock

Price: €211.69
Size: 20 ug
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