GDF15 protein (30R-AM045)
Purified recombinant Human GDF15 protein
Overview
Overview
| Synonyms | GDF 15, GDF 15 protein, GDF15, GDF-15 protein, GDF-15, GDF-15 protein, Prostate differentiation factor protein, MIC-1 protein, Placental TGFbeta protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | User optimized |
Specifications
| Residues | Region of GDF15 protein corresponding to amino acids ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI. |
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| Expression System | CHO cells |
| Grade & Purity | > 98% pure |
| Form & Buffer | Lyophilized from 10mM Sodium Citrate, pH 3.0. Reconstitute in water to a concentration of 0.1 - 1.0 mg/ml. |
Usage & Assay Information
| Bioactivity | Determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1.0-2.0 ug/ml. |
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Storage & Safety
| Storage | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Endotoxin Levels | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
General Information
| Biological Significance | GDF-15 belongs to the TGF beta cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. |
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