GDF5 protein (His tag) (80R-1159)

Purified recombinant Human GDF5 protein

Synonyms GDF 5 protein, SYNS2 protein, GDF5, Growth differentiation factor 5 protein, GDF-5 protein, LAP4 protein, GDF-5, GDF 5, BMP14 protein, , Growth differentiation factor 5 Cartilage derived morphogenetic protein 1 protein, OS5 protein, CDMP1 protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of GDF5 protein (His tag) (80R-1159)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 382-501 amino acids: MGSSHHHHHH SSGLVPRGSH MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R
Expression System E.coli
Grade & Purity > 95% pure
Molecular Weight 15.8 kDa (141aa), confirmed by MALDI-TOF.
Tag/Conjugate His tag
Form & Buffer Supplied as a liquid in 10mM sodium citrate, pH 3.5, 10% glycerol.
Concentration 0.5 mg/ml

Storage & Safety

Storage Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels < 1.0 EU per ug of protein (determined by LAL method)

General Information

Biological Significance Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in chondrogenesis and chondrocyte metabolism, tendon and ligament tissue formation, and bone repair. It also increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinson's disease. GDF-5, fused to His-tag at N-terminus, was expressed as insoluble protein aggregate in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

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Images

  • Coomassie Blue stained SDS-PAGE of GDF5 protein (His tag) (80R-1159) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: €239.92
Size: 100 ug
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