GFAP antibody (20C-CR8013R)
Rabbit polyclonal GFAP antibody
|Synonyms||Polyclonal GFAP antibody, Anti-GFAP antibody, Glial Fibrillary Acid Protein antibody, Glial marker, Glial Filament Protein antibody|
|Cross Reactivity||Human, dog, cat, mouse, rat|
|Immunogen||GFAP antibody was raised in rabbit using GFAP isolated from bovine spinal cord as the immunogen.|
Immunohistochemical staining using GFAP antibody (20C-CR8013R)
Image illustrating progressive glial activation in nGD mice. Low magnification of coronal sections of 12 day old, 16 day old and 21 day old nGD mice showing onset and progression of activated microglia (Mac2, A) or astrocytosis (GFAP, B) through of immunohistochemical staining for markers. Pronounced and localized microglial activation and astrocytosis were evident in multiple brain regions, occurring at the same stage of disease progression and increasing with age. No staining is observed in control brains (B). Schematic diagrams indicate the rostrocaudal level of each section. Scale bar = 1 mm.
|Form & Buffer||Lyophilized neat serum with no preservatives. Reconstitute by adding 100 ul sterile water.|
Usage & Assay Information
|Usage Recommendations||IHC-P: 1:50-1:250, WB: 1:500-1:1,000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biohazard Information||This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.|
|Biological Significance||The glial fibrillary acidic protein (GFAP) gene encodes one of the major intermediate filament proteins of mature astrocytes with multiple isoforms present in the CNS. GFAP is expressed both in the neurospheres from the subventricular zone and the olfactory bulb.|
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