GHR protein (80R-4402)
Purified Recombinant GHR protein
Overview
Overview
| Synonyms | GHR protein, GHR/BP protein |
|---|---|
| Species | Rat |
| Applications | SDS-PAGE |
Specifications
| Residues | 19-265 aa: FPGSGATPAT LGKASPVLQR INPSLRESSS GKPRFTKCRS PELETFSCYW TEGDDHNLKV PGSIQLYYAR RIAHEWTPEW KECPDYVSAG ANSCYFNSSY TSIWIPYCIK LTTNGDLLKE KCFTVDEIVQ PDPPIGLNWT LLNISLPGIR GDIQVSWQPP PSADVLKGWI ILEYEIQYKE VNETKWKTMS PIWSTSVPLY SLRLDKEHEV RVRSRQRSFE KYSEFSEVLR VTFPQMDTLA ACEEDFRLEH HHHHH |
|---|---|
| Expression System | Insect cells |
| Grade & Purity | > 95% pure |
| Molecular Weight | 29.4 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 500 ug/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage or aliquout and store at -20 to -70 deg C for long term storage. Avoid repeat freeze/thaw cycles |
|---|---|
| Endotoxin Levels | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
General Information
| Biological Significance | GHR, also known as growth hormone receptor, is a member of the cytokine receptor superfamily. GHR forms a complex with a tyrosine kinase, suggesting involvement of a ligand-activated tyrosine kinase in intracellular signaling by growth hormone (GH). Binding of GH to its receptor results in dimerization of the receptor, phosphorylation of the tyrosine kinase JAK2 and of the receptor, followed by a cascade of protein phosphorylations. |
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