GLE1 antibody (70R-13059)
Affinity purified Rabbit polyclonal GLE1 antibody
Overview
Overview
| Synonyms | Polyclonal GLE1 antibody, Anti-GLE1 antibody, nucleoporin GLE1 antibody, LCCS1 antibody, GLE1L antibody, GLE1 antibody, hGLE1 antibody, GLE1 RNA export mediator homolog (yeast) antibody, GLE1-like RNA export mediator antibody, GLE-1 antibody, GLE 1, GLE-1, GLE 1 antibody, GLE1, LCCS antibody, GLE1-like protein antibody |
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| Cross Reactivity | Human |
| Applications | ICC, IF, IHC-P, WB |
| Immunogen | GLE1 antibody was raised in rabbit using a recombinant protein fragment contain a sequence corresponding to a region within amino acids 414 and 646 of GLE1 |
Images
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | GLE1 antibody was purified by antigen-affinity chromatography |
| Molecular Weight | 75 kDa |
| Form & Buffer | Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative. |
| Concentration | 1 mg/ml |
Usage & Assay Information
| Usage Recommendations | IF:1:100-1:1000, ICC:1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000 |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. |
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