Polyclonal Glucocorticoid Receptor beta antibody, Anti-Glucocorticoid Receptor beta antibody, GCCR antibody, GRL antibody, glucocorticoid receptor antibody, nuclear receptor subfamily 3 group C member 1 variant DL-1 antibody, glucocorticoid nuclear receptor variant 1 antibody, GR antibody, NR3C1 antibody, nuclear receptor subfamily 3 group C member 1 (glucocorticoid receptor) antibody, nuclear receptor subfamily 3 group C member 1 variant NS-1 antibody, GCR antibody
Cross Reactivity
Human
Applications
IHC-P, WB
Immunogen
Glucocorticoid Receptor beta antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 1 and 265 of Glucocorticoid Receptor beta
Immunohistochemical staining using Glucocorticoid Receptor beta antibody (70R-12560)
Immunohistochemical staining of paraffin-embedded Hela xenograft using Glucocorticoid Receptor beta antibody at a dilution of 1:500
Glucocorticoid Receptor beta antibody
Immunohistochemical staining using Glucocorticoid Receptor beta antibody (70R-12560)
Immunohistochemical staining of paraffin-embedded Hela xenograft using Glucocorticoid Receptor beta antibody at a dilution of 1:500
Western blot analysis using Glucocorticoid Receptor beta antibody (70R-12560)
Western blot analysis of 30 ug of whole cell lysate (A: A431) using a 7.5 % SDS PAGE gel and Glucocorticoid Receptor beta antibody at a dilution of 1:1000
Specifications
Host
Rabbit
Isotype
IgG
Method of Purification
Glucocorticoid Receptor beta antibody was purified by antigen-affinity chromatography
Molecular Weight
82 kDa
Form & Buffer
Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
General Information
Biological Significance
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance.