GM2A protein (GST tag) (80R-3110)
Purified recombinant GM2A protein (GST tag)
Overview
Overview
| Synonyms | Cerebroside sulfate activator protein, GM2 AP protein, Shingolipid activator 3 protein, SAP 3 protein, Ganglioside GM2 activator isoform short protein, Ganglioside GM2 activator protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | ELISA, SDS-PAGE, WB |
Specifications
| Expression System | E.coli |
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| Grade & Purity | > 95% pure |
| Molecular Weight | 44 kDa |
| Tag/Conjugate | GST tag |
| Form & Buffer | Supplied in liquid form in 6M guanidine hydrochloride and 20mM Tris buffer |
Storage & Safety
| Storage | Store at 4 deg C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 deg C, avoid repeat freeze/thaw cycles |
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General Information
| Biological Significance | GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. |
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