Goat anti Human Kappa light chain (20-S2301G000-S4)
Goat anti Human Kappa light chain antibody
Overview
Overview
| Synonyms | Polyclonal Goat anti Human free Kappa Light Chain antibody,Goat anti-Human free Kappa Light Chain antibody, Human free Kappa Light Chain antibody |
|---|---|
| Specificity | Human |
| Cross Reactivity | Monospecific for Kappa Light Chain. |
| Applications | User optimized |
| Immunogen | Kappa light chain antibody was raised in goat using kappa light chain isolated from human bance-Jones urine as the immunogen. |
Specifications
| Host | Goat |
|---|---|
| Grade & Purity | Standard grade |
| Form & Buffer | Supplied delipidated, defibrinated, and 0.2 um filtered in 0.2M Tris, pH 7.6, with 0.5M NaCl and 0.09% NaN3. |
| Concentration | 1.56 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | There are two types of light chain in humans (as in other mammals), kappa chain, encoded by the immunoglobulin kappa locus ([email protected]) on chromosome 2 and lambda chain, encoded by the immunoglobulin lambda locus ([email protected]) on chromosome 22. Antibodies are produced by B lymphocytes, each expressing only one class of light chain. Once set, light chain class remains fixed for the life of the B lymphocyte. In a healthy individual, the total kappa to lambda ratio is roughly 2:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm. |
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