GOPC protein (His tag) (80R-1261)
Purified recombinant Human GOPC protein
|Synonyms||Golgi associated PDZ and coiled coil motif containing protein, CAL protein, GOPC1 protein, PDZ protein interacting specifically with TC10 protein, GOPC 1 protein, PDZ/coiled coil domain binding partner for the rho family GTPase TC 10 protein, FIG Fused in glioblastoma protein, FIG protein, Protein interacting specifically with Tc 10 protein, dJ94G16.2 protein, Golgi associated PDZ and coiled coil motif containing protein protein, Protein interacting specifically with Tc10., PIST protein, OTTHUMP00000040403 protein, PDZ/coiled coil domain binding partner for the rho family GTPase TC10 protein, dJ94G16.2 protein, PDZ protein interacting specifically with TC 10 protein, Golgi-associated PDZ and coiled-coil motif-containing protein CFTR associated ligand protein|
Coomassie Blue stained SDS-PAGE of GOPC protein (His tag) (80R-1261)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||278-454 amino acids: MGSSHHHHHH SSGLVPRGSH MIRKVLLLKE DHEGLGISIT GGKEHGVPIL ISEIHPGQPA DRCGGLHVGD AILAVNGVNL RDTKHKEAVT ILSQQRGEIE FEVVYVAPEV DSDDENVEYE DESGHRYRLY LDELEGGGNP GASCKDTSGE IKVLQGFNKK AVTDTHENGD LGTASETPLD DGASKLDDLH TLYHKKSY|
|Grade & Purity||> 90% pure|
|Molecular Weight||21.5 kDa (198aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||GOPC, also known as PIST, is a PDZ domain-containing Golgi protein. This protein functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, GOPC is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding GOPC are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis. Recombinant GOPC protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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