Aliquot and store at -20 deg C. Avoid repeated freeze/thaw cycles
General Information
Biological Significance
Granzyme A is the most abundant of the proteases occurring in CTL granules. It is homologous to other serine esterases, including other granyzmes, mast cell proteases, and neutrophil cathepsins. Granzyme A is unique among granzymes in that it is a disulfide linked homodimer. Granzyme B is thought to be a rapidly acting apoptotic enzyme, while Granzyme A is thought to be slow acting. Granzyme A is a 28 kD protein. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.