GRB2 protein (His tag) (80R-1127)
Purified recombinant Human GRB2 protein
|Synonyms||Grb3 3 protein, Ash protein protein, Protein ASH protein, MSTP084 protein, GRB2 adapter protein protein, Epidermal growth factor receptor binding protein protein, Growth factor receptor bound protein 2 protein, SEM5 protein, GRB2, GRB 2, EGFRBP-GRB2 protein, GRB 2 protein, HT027 protein, GRB-2, Growth factor receptor-bound protein 2 isoform 1 Abundant SRC homology protein, OTTHUMP00000166098 protein, Growth factor receptor bound protein 3 protein, Growth factor receptor-bound protein 2 isoform 1 protein, Adapter protein GRB2 protein, OTTHUMP00000166096 protein, MST084 protein, SH2/SH3 adapter GRB2., OTTHUMP00000166097 protein, ASH protein, Epidermal growth factor receptor binding protein GRB2 protein, GRB-2 protein, EGFRBP GRB2 protein, GRB3-3 protein, GRB 2 protein|
Coomassie Blue stained SDS-PAGE of GRB2 protein (His tag) (80R-1127)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-217 amino acids: MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV|
|Grade & Purity||> 95% pure|
|Molecular Weight||27 kDa (237 aa), confirmed by MALDI-TOF.|
|Form & Buffer||20mM Tris-HCl buffer, pH 8.0, containing 30% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. GRB2 is widely expressed and also binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. Recombinant human GRB2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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