GSK3 alpha protein (GST Fusion) (80R-2554)
Purified recombinant Human GSK3 alpha-GST Fusion protein
Overview
Overview
| Synonyms | GSK-3 alpha protein, GSK 3 alpha, GSK 3 alpha protein, GSK-3 alpha, GSK protein, GSK3 alpha, Glycogen synthase kinase-3 protein, GSK-3 protein |
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| Species | Human |
| Protein Type | Recombinant |
Specifications
| Expression System | E.coli |
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| Method of Purification | GSK3 alpha-GST Fusion protein was purified using a a proprietary chromatographic technique. |
| Molecular Weight | 37.0 kDa |
| Tag/Conjugate | GST tag |
| Form & Buffer | Supplied in liquid form in storage buffer containing 20 mM Tris-HCl (pH 7.5), 50 mM NaCl, 2 mM EDTA, 1 mM DTT, and 50% glycerol |
Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility. |
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