GSKIP protein (His tag) (80R-1765)
Purified recombinant Human GSKIP protein
|Synonyms||GSK3-beta interaction protein, protein|
Coomassie Blue stained SDS-PAGE of GSKIP protein (His tag) (80R-1765)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-139 amino acids: MGSSHHHHHH SSGLVPRGSH METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE AFGNALLQRL EALKRDGQS|
|Grade & Purity||> 95% pure|
|Molecular Weight||17.8 kDa (159aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0. containing 1mM DTT, 10% glycerol and 50mM NaCl|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||GSKIP (GSK3 beta interaction protein) is defined as a naturally occurring protein that is homologous with the GSK3beta interaction domain of Axin and is able to negatively regulate GSK3 beta of the Wnt signaling pathway. GSKIP may affect GSK3 beta activity on neurite outgrowth by inhibiting the specific phosphorylation of tau (ser396). Recombinant human GSKIP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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