Monoclonal Hairy and Enhancer of Split 1 antibody, Anti-Hairy and Enhancer of Split 1 antibody, Hes1 Hairy and enhancer of split 1 Hairy Enhancer of Split 1 Hairy Homolog Hairy like HHL HL HRY Transcription factor HES 1 antibody, Q8IXV0 antibody
Cross Reactivity
Human, Mouse, Rat
Applications
ELISA, IP, WB
Immunogen
Hairy and Enhancer of Split 1 antibody was raised in Mouse using a His-tagged recombinant human Hes1 protein purified from E.coli as the immunogen
Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles
General Information
Biological Significance
The Notch signaling pathway is important for cell-cell communication, which involve gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. It critically influences cell proliferation, differentiation, and apoptosis in metazoans. The hairy and enhancer of split (HES) family is a basic helix-loop-helix (bHLH) type trancriptional repressor and acts as Notch effectors by negatively regulating expression of downstream target genes such as tissue-specific transcription factors. HES-1 is an upstream negative regulator of REST expression. Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells.