Haptoglobin antibody (10C-CR2114M1)

Mouse monoclonal Haptoglobin antibody

Synonyms Monoclonal Haptoglobin antibody, Anti-Haptoglobin antibody, alpha polypeptide antibody, HPA1S antibody, Haptoglobin antibody, HP2 alpha2 antibody, Hp2 alpha antibody, beta polypeptide antibody, Haptoglobin, HP antibody, HPT antibody, MGC111141 antibody
Specificity Human haptoglobin
Cross Reactivity To be determined by end-user
Applications User optimized
Immunogen Haptoglobin antibody was raised in mouse using purified haptoglobin from pooled human plasma, (containing the three major haplotypes), as the immunogen.

Specifications

Host Mouse
Clone 637400
Isotype IgG1
Form & Buffer Ascities fluid with 15mM NaN3.
Concentration Batch dependent - please inquire should you have specific requirements

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance Haptoglobin (abbreviated as Hp) is a protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobulin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis free hemoglobin will be released into circulation and hence haptoglobin will bind the Hb. This causes a decline in Hp levels. Conversely, in extravascular hemolysis the reticuloendothelial system, especially splenic monocytes, phagocytose the erythrocytes and hemoglobin is not released into circulation and hence haptoglobin levels are normal.

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Availability: In stock

Price: €277.55
Size: 100 ul
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