HAX1 antibody (10R-1153)

Mouse monoclonal HAX1 antibody

Synonyms Monoclonal HAX1 antibody, Anti-HAX1 antibody, HAX -1 antibody, HS1BP1 antibody, HCLS1 associated protein X-1 antibody, HAX 1 antibody, HCLSBP1 antibody, HAX 1, HCLS1 (and PKD2) associated protein antibody, HAX -1, HAX1
Specificity Human
Cross Reactivity To be determined by end-user.
Applications ELISA, WB
Immunogen HAX1 antibody was raised in mouse using recombinant human HAX1 (1-279aa) purified from E. coli as the immunogen.

Images

Western Blot analysis of HAX1 antibody (10R-1153)

Cell lysates of MCF7 (30 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human HAX1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Host Mouse
Clone AT3C5
Isotype IgG2b kappa
Source Anti-human HAX1 antibody, clone AT3C5, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human HAX1 protein.
Method of Purification HAX1 antibody was purified by protein-G affinity chromatography
Form & Buffer Supplied as a liquid in PBS, pH 7.4, with 0.1% NaN3.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1:1000-1:2,000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1 (HS1), one of the substrates of receptor-coupled tyrosine kinases activated during clonal expansion and deletion in lymphoid cells. It also interacts with the product of the polycystic kidney disease 2 (PKD2) gene and with the F-actin-binding protein, cortactin. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.

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Images

  • Western Blot analysis of HAX1 antibody (10R-1153) | Cell lysates of MCF7 (30 ug) were resolved by SDS-PAGE, transferred to nitrocellulose membrane and probed with anti-human HAX1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Availability: In stock

Price: €249.33
Size: 100 ul
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