HCV-NS5a protein (His tag) (80R-3872)
Purified recombinant HCV-NS5a protein (His tag)
Overview
Overview
| Synonyms | Polyprotein protein, Hepatitis C virus non-structural 5a protein membrane anchor protein |
|---|---|
| Species | Viral |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
SDS Page of HCV-NS5a protein (His tag) (80R-3872)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 2210-2306 aa: MGSSHHHHHH SSGLVPRGSH MSLKATCTAN HDSPDAELIE ANLLWRQEMG GNITRVESENKVVILDSFDP LVAEEDEREV SVPAEILRKS RRFARALPVW ARPDYNPPLV ETWKKPDY |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 90% pure |
| Method of Purification | HCV-NS5a protein was purified by proprietary chromatographic techniques |
| Molecular Weight | 13.4 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% glycerol, 1mM DTT |
| Concentration | 250 ug/ml |
Storage & Safety
| Storage | Can be stored at 4 deg C short term. For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles |
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General Information
| Biological Significance | NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. This protein down-regulates viral IRES translation initiation and mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. NS5a seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication. |
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