HCV-NS5a protein (His tag) (80R-3872)

Purified recombinant HCV-NS5a protein (His tag)

Synonyms Polyprotein protein, Hepatitis C virus non-structural 5a protein membrane anchor protein
Species Viral
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS Page of HCV-NS5a protein (His tag) (80R-3872)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 2210-2306 aa: MGSSHHHHHH SSGLVPRGSH MSLKATCTAN HDSPDAELIE ANLLWRQEMG GNITRVESENKVVILDSFDP LVAEEDEREV SVPAEILRKS RRFARALPVW ARPDYNPPLV ETWKKPDY
Expression System E.coli
Grade & Purity > 90% pure
Method of Purification HCV-NS5a protein was purified by proprietary chromatographic techniques
Molecular Weight 13.4 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% glycerol, 1mM DTT
Concentration 250 ug/ml

Storage & Safety

Storage Can be stored at 4 deg C short term. For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles

General Information

Biological Significance NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. This protein down-regulates viral IRES translation initiation and mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. NS5a seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication.

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Images

  • SDS Page of HCV-NS5a protein (His tag) (80R-3872) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: €224.95
Size: 20 ug
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