HCV-NS5b protein (His tag) (80R-3809)
Purified recombinant HCV-NS5b protein (His tag)
Overview
Overview
| Synonyms | Polyprotein protein, protein |
|---|---|
| Species | Viral |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
SDS Page of HCV-NS5b protein (His tag) (80R-3809)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 2634-2752 aa: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSPMGF SYDTRCFDST VTESDIRTEE AIYQCCDLDP QARVAIKSLT ERLYVGGPLT NSRGENCGYR RCRASGVLTT SCGNTLTCYI KARAACRAAG LQDCTMLVCG DDLVVICESA GVQED |
|---|---|
| Expression System | E.coli |
| Grade & Purity | > 90% pure |
| Method of Purification | HCV-NS5b protein was purified by proprietary chromatographic techniques |
| Molecular Weight | 17.0 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
| Concentration | 250 ug/ml |
Storage & Safety
| Storage | Can be stored at 4 deg C short term. For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles |
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General Information
| Biological Significance | Hepatitis C virus genotype 1 is a core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. It modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit and also regulates many host cellular functions such as signaling pathways and apoptosis. It prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. |
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