HCV-NS5b protein (His tag) (80R-3809)

Purified recombinant HCV-NS5b protein (His tag)

Synonyms Polyprotein protein, protein
Species Viral
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS Page of HCV-NS5b protein (His tag) (80R-3809)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 2634-2752 aa: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSPMGF SYDTRCFDST VTESDIRTEE AIYQCCDLDP QARVAIKSLT ERLYVGGPLT NSRGENCGYR RCRASGVLTT SCGNTLTCYI KARAACRAAG LQDCTMLVCG DDLVVICESA GVQED
Expression System E.coli
Grade & Purity > 90% pure
Method of Purification HCV-NS5b protein was purified by proprietary chromatographic techniques
Molecular Weight 17.0 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Concentration 250 ug/ml

Storage & Safety

Storage Can be stored at 4 deg C short term. For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles

General Information

Biological Significance Hepatitis C virus genotype 1 is a core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. It modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit and also regulates many host cellular functions such as signaling pathways and apoptosis. It prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication.

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Images

  • SDS Page of HCV-NS5b protein (His tag) (80R-3809) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: €377.91
Size: 50 ug
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