HCVE2 protein (His tag) (80R-3891)

Purified recombinant HCVE2 protein (His tag)

Synonyms E2 protein
Species Viral
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS Page of HCVE2 protein (His tag) (80R-3891)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 482-671 aa: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSERPY CWHYPPRPCG IVPAKSVCGP VYCFTPSPVV VGTTDRSGAP TYSWGANDTD VFVLNNTRPP LGNWFGCTWM NSTGFTKVCG APPCVIGGVG NNTLLCPTDC FRKHPEATYS RCGSGPWITP RCMVDYPYRL WHYPCTINYT IFKVRMYVGG VEHRLEAACN WTRGERCDLE DRDRSELSPL LLSTTQ
Expression System E.coli
Grade & Purity > 80% pure
Method of Purification HCVE2 protein was purified by proprietary chromatographic techniques
Molecular Weight 25.4 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Concentration 250 ug/ml

Storage & Safety

Storage Can be stored at 4 deg C short term. For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles

General Information

Biological Significance E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells.

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Images

  • SDS Page of HCVE2 protein (His tag) (80R-3891) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: €224.95
Size: 100 ug
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