HDAC6 antibody (70R-14138)
Affinity purified Rabbit polyclonal HDAC6 antibody
Overview
Overview
| Synonyms | Polyclonal HDAC6 antibody, anti-HDAC6 antibody, HDAC 6 antibody, HD6 antibody, HDAC 6, JM21 antibody, HDAC-6 antibody, HDAC-6 antibody, HDAC-6, histone deacetylase 6 antibody, HDAC6 |
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| Applications | IHC-P, WB |
| Immunogen | HDAC6 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human HDAC6, different from the related rat and Rabbit sequences by two amino acids, as the immunogen |
Images
Western blot analysis using HDAC6 antibody (70R-14138)
Lane 1: Rat Brain Tissue Lysate, Lane 2: Rat Testis Tissue Lysate, Lane 3: HELA Cell Lysate
Specifications
| Host | Rabbit |
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| Isotype | IgG |
| Method of Purification | HDAC6 antibody was purified by affinity chromatography |
| Form & Buffer | Supplied in lyophilized form |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by the end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Human HDAC6 possesses two separate putative catalytic domains, both of which are fully functional and contribute independently to the overall activity of HDAC6. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. HDAC6 may participate in coordinating expression of a group of genes involved in the remoldeling of chromatin during cell differentiation. |
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