HE4 protein (30-1338)
Standard grade native HumanHE4 protein
Overview
Overview
| Synonyms | EDDM4 protein, HE-4 protein, HE 4 protein, WAP5 protein, WFDC2 protein, Epididymis-specific he4 protein, Human Epididymal 4 protein, DJ461P17.6 protein, HE4, Cell Derived HE4 protein, HE4 antigen |
|---|---|
| Species | Human |
| Protein Type | Native |
Specifications
| Source | Ascitic fluid |
|---|---|
| Grade & Purity | Standard grade |
| Method of Purification | HE4 protein was purified by ultrafiltration and differential precipitation |
| Form & Buffer | Supplied in liquid form in PBS with sodium azide |
Storage & Safety
| Storage | Store at -70 deg C in small aliquots. Avoid repeated freeze thaw cycles. |
|---|---|
| Biohazard Information | Tested in HBs antigen EIA, HCV Ab, HIV I/II Ab EIA. |
General Information
| Product Use | This HE4 protein may be used as an immunogen for antibody generation or in in vitro studies. |
|---|---|
| Biological Significance | HE4, or WAP four-disulfide core domain 2, is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and it functions as a protease inhibitor in many family members.However, the biologic function of HE4 is unknown. |
| Implications in Disease | HE4 has been shown to be overexpressed in 93% of serous, 100% of endometrioid, and 50% of clear cell ovarian carcinomas. |
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