Heat Labile Enterotoxin antibody (10-1016)
Mouse monoclonal Heat Labile Enterotoxin antibody
Overview
Overview
| Synonyms | Monoclonal Heat Labile Enterotoxin antibody, Anti-Heat Labile Enterotoxin antibody, Enterotoxin antibody |
|---|---|
| Specificity | Reactive to Heat-labile enterotoxin (LT) |
| Cross Reactivity | Cross reactive to Cholera toxin (CT) |
| Applications | ELISA |
| Immunogen | Heat Labile Enterotoxin antibody was raised in mouse using Heat-labile enterotoxin as the immunogen. |
| Assay Information | Use 10-1016 as the capture antibody with 10-1017 as the detection antibody for sandwich immunoassays |
Specifications
| Host | Mouse |
|---|---|
| Clone | M120532 |
| Isotype | IgG1 |
| Grade & Purity | > 95% pure |
| Method of Purification | Heat Labile Enterotoxin antibody was purified by Protein A or G affinity purification |
| Form & Buffer | Supplied as a liquid in PBS, pH 7.4, 3mM KCl, 1.5mM KH2PO4, 140mM NaCl, 8.0mM Na2HPO4 |
| Concentration | 1-3 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term or -20 deg C for longer storage. Avoid repeated freeze/thaw cycles. |
|---|---|
| Biohazard Information | This product contains sodium azide as a preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. |
General Information
| Biological Significance | Heat-labile enterotoxin is a type of labile toxin found in Escherichia coli that is inactivated at high temperatures. It acts similarly to the cholera toxin by raising cAMP levels through ADP-ribosylation of the alpha-subunit of a Gs protein leading to the constitutive activation of adenylate cyclase. Elevated cAMP levels stimulate secretion of Chloride ions and water from the enterocyte into the gut lumen, thus causing watery diarrhea. In addition to its effects on chloride secretion, which involve the same steps as the effects of cholera toxin, heat-labile enterotoxin binds additional substrates: lipopolysaccharide on the surface of E. coli cells and A-type blood antigens. The importance of these binding events is not yet known. |
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Heat Labile Enterotoxin antibody
Mouse monoclonal Heat Labile Enterotoxin antibody