Hepatitis C Virus NS3 Genotype-1b protein (30R-AH052)
Hepatitis C Virus NS3 Genotype-1b recombinant protein
Overview
Overview
| Synonyms | Hepatitis C NS3 protein, Hepatitis C Virus protein, Hep C protein, Hepatitis C protein, HCV NS3-1b protein |
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| Species | Viral |
| Protein Type | Recombinant |
| Applications | ELISA, WB |
Specifications
| Residues | The E.coli derived 26.2 kDa recombinant protein contains the HCV NS3 c33c immunodominant regions. The 252 amino acid protein is fused to 6x His tag. |
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| Expression System | E.coli |
| Grade & Purity | > 95% pure |
| Method of Purification | Hepatitis C Virus NS3 Genotype-1b protein was purified by a proprietary chromatographic technique. |
| Molecular Weight | 26.2 kDa |
| Tag/Conjugate | His tag |
| Form & Buffer | 50mM Na3PO4, pH 8.3, with 10mM DTT. |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6). |
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