Hepatitis C Virus NS4 Genotype 5 protein (30R-AH060)
Hepatitis C Virus NS4 Mosaic Genotype-5 recombinant protein
Overview
Overview
| Synonyms | Hep C protein, HCV Recombinant protein, Hepatitis C protein, HCV NS4 Genotype 5 protein, HCV protein |
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| Species | Viral |
| Protein Type | Recombinant |
| Applications | ELISA, WB |
Specifications
| Residues | The E.coli derived recombinant protein contains the HCV NS4 immunodominant regions, amino acids 1691-1710, 1712-1733 and 1921-1940, fused with a GST tag at N-terminus. |
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| Expression System | E.coli |
| Grade & Purity | > 95% pure |
| Method of Purification | Hepatitis C Virus NS4 Genotype 5 protein was purified by a proprietary chromatographic technique. |
| Tag/Conjugate | GST tag |
| Form & Buffer | 1.5M urea, with 25mM Tris-HCl, pH-8, 0.2% Triton-X and 50% glycerol. |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6). |
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