Hepatitis C Virus NS5 protein (30R-AH075)
Purified recombinant Hepatitis C Virus NS5 protein
Overview
Overview
| Synonyms | HCV Recombinant protein, Hep C protein, Hepatitis C protein, HCV NS5 protein, HCV protein |
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| Species | Viral |
| Protein Type | Recombinant |
| Applications | ELISA, WB |
Specifications
| Residues | The E.coli derived recombinant protein contains the HCV NS5 immunodominant regions, amino acids 2061-2302. The protein is fused with GST at N-terminus. |
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| Expression System | E.coli |
| Grade & Purity | > 95% pure |
| Method of Purification | Hepatitis C Virus NS5 protein was purified by a proprietary chromatographic technique. |
| Tag/Conjugate | GST tag |
| Form & Buffer | 25mM tris-HCl, pH-8, with 1.5M urea, 0.2% Triton-X and 50% glycerol. |
Usage & Assay Information
| Usage Recommendations | Optimal conditions to be determined by end user |
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Storage & Safety
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6). |
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