HEXIM1 protein (His tag) (80R-1252)
Purified recombinant Human HEXIM1 protein
|Synonyms||Hexamethylene bis acetamide inducible transcript 1 protein, HIS1 protein, Hexamethylene bis acetamide inducible 1 protein, HEXIM 1, HEXIM 1 protein, HEXIM-1, EDG 1 protein, Hexamethylene bis-acetamide inducible 1 Cardiac lineage protein 1 protein, EDG1 protein, MAQ1 protein, FLJ13562 protein, Hexamethylene bis acetamide inducible protein protein, MAQ 1 protein, CLP 1 protein, HEXIM 1 protein, HMBA inducible protein, HIS 1 protein, HEXIM1, CLP1 protein, HEXIM-1 protein, Menage a quatre 1., HEXIM1 protein protein|
Coomassie Blue stained SDS-PAGE of HEXIM1 protein (His tag) (80R-1252)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-359 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMAE PFLSEYQHQP QTSNCTGAAA VQEELNPERP PGAEERVPEE DSRWQSRAFP QLGGRPGPEG EGSLESQPPP LQTQACPESS CLREGEKGQN GDDSSAGGDF PPPAEVEPTP EAELLAQPCH DSEASKLGAP AAGGEEEWGQ QQRQLGKKKH RRRPSKKKRH WKPYYKLTWE EKKKFDEKQS LRASRIRAEM FAKGQPVAPY NTTQFLMDDH DQEEPDLKTG LYSKRAAAKS DDTSDDDFME EGGEEDGGSD GMGGDGSEFL QRDFSETYER YHTESLQNMS KQELIKEYLE LEKCLSRMED ENNRLRLESK RLGGDDARVR ELELELDRLR AENLQLLTEN ELHRQQERAP LSKFGD|
|Grade & Purity||> 90% pure|
|Molecular Weight||44.8 kDa (396aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This protein has been shown to form a protein-RNA complex composed of 7SK small nuclear RNA and positive transcription elongation factor b (P-TEFb), which is composed of cyclin-dependent kinase 9 (CDK9) and cyclin T1, and to inhibit the kinase activity of CDK9, thereby suppressing RNA polymerase II-dependent transcriptional elongation. Recombinant HEXIM1 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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