HGF protein (30R-AH020)

Purified recombinant Human HGF protein

Synonyms SF protein, Scatter Factor protein, Hepatopoietin protein, Hepatocyte Growth Factor protein, HPTA protein
Species Human
Protein Type Recombinant
Applications User optimized

Specifications

Expression System Hi-5 cells
Grade & Purity > 98% pure
Form & Buffer Lyophilized from 0.1M L-Arginine HCL, with 10mM tris, pH8.0 and 200mM NaCl. Reconstitute in water to a concentration of 0.5 mg/ml.

Usage & Assay Information

Bioactivity The ED50 was determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells was found to be in the range of 20.0-40.0 ng/ml.

Storage & Safety

Storage Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

General Information

Biological Significance HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and Mouse HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (a-chain and beta-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer.

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Availability: In stock

Price: €211.69
Size: 10 ug
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