HIF1a protein (30R-1042)

Purified recombinant Human HIF1 alpha protein

Synonyms Hifa-1 protein, Hif1a, HIF 1A protein, Hifa 1 protein, ARNT interacting protein protein, MOP1 protein, HIF 1alpha protein, bHLHe78 protein, Hif-1 alpha (530-826 aa) protein, HIF-1 alpha protein, Member of PAS protein 1 protein, Hifa-1, Hypoxia-inducible factor-1a Basic helix loop helix PAS protein MOP1 protein, MOP 1 protein, Member of the PAS Superfamily 1 protein, PASD8 protein, Hypoxia inducible factor 1 alpha isoform I.3 protein, Basic-helix-loop-helix-PAS protein MOP1 protein, Hypoxia-inducible factor 1 alpha protein, HIF1A protein, HIF1 alpha protein, PASD 8 protein, , Member of PAS protein 1 protein, Member of PAS superfamily 1 protein, Hifa 1, ARNT-interacting protein protein, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor protein, Hypoxia inducible factor 1 alpha subunit protein, HIF1 A protein, Hypoxia inducible factor 1 alpha protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Specifications

Residues 530-826 amino acids: MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN
Expression System E.coli
Grade & Purity > 95% pure
Molecular Weight 32.8 kDa (298aa), confirmed by MALDI-TOF. (The recombinant protein appeared as a 40 kDa band on SDS-PAGE)
Form & Buffer Supplied as a liquid in 20mM Tris-HCl, pH7.5, containing 1mM DTT.
Concentration 1 mg/ml

Storage & Safety

Storage Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1 beta subunit and one of three subunits (Hif-1alpha, Hif-2alpha or Hif-3alpha). The activation of Hif-1 alpha is closely associated with a variety of tumors and oncogenic pathways. Hif-1 alpha consists of DNA binding domain (DBD domain), Dimerization domain and C-terminal regulatiory domains, including two transactivation domains (TAD), an oxygen-dependent degradation(ODD) domain, and inhibitory domains. Hif-1 alpha (530-826 residues) contains two TAD and inhibitory domain. Recombinant Hif-1 alpha (530-826 residues) was expressed in E. coli and purified by using conventional chromatography techniques.

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Availability: In stock

Price: €169.35
Size: 100 ug
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