HIF1a protein (30R-1042)
Purified recombinant Human HIF1 alpha protein
|Synonyms||Hifa-1 protein, Hif1a, HIF 1A protein, Hifa 1 protein, ARNT interacting protein protein, MOP1 protein, HIF 1alpha protein, bHLHe78 protein, Hif-1 alpha (530-826 aa) protein, HIF-1 alpha protein, Member of PAS protein 1 protein, Hifa-1, Hypoxia-inducible factor-1a Basic helix loop helix PAS protein MOP1 protein, MOP 1 protein, Member of the PAS Superfamily 1 protein, PASD8 protein, Hypoxia inducible factor 1 alpha isoform I.3 protein, Basic-helix-loop-helix-PAS protein MOP1 protein, Hypoxia-inducible factor 1 alpha protein, HIF1A protein, HIF1 alpha protein, PASD 8 protein, , Member of PAS protein 1 protein, Member of PAS superfamily 1 protein, Hifa 1, ARNT-interacting protein protein, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor protein, Hypoxia inducible factor 1 alpha subunit protein, HIF1 A protein, Hypoxia inducible factor 1 alpha protein|
Coomassie Blue stained SDS-PAGE of Hif1a protein (30R-1042)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||530-826 amino acids: MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN|
|Grade & Purity||> 95% pure|
|Molecular Weight||32.8 kDa (298aa), confirmed by MALDI-TOF. (The recombinant protein appeared as a 40 kDa band on SDS-PAGE)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl, pH7.5, containing 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1 beta subunit and one of three subunits (Hif-1alpha, Hif-2alpha or Hif-3alpha). The activation of Hif-1 alpha is closely associated with a variety of tumors and oncogenic pathways. Hif-1 alpha consists of DNA binding domain (DBD domain), Dimerization domain and C-terminal regulatiory domains, including two transactivation domains (TAD), an oxygen-dependent degradation(ODD) domain, and inhibitory domains. Hif-1 alpha (530-826 residues) contains two TAD and inhibitory domain. Recombinant Hif-1 alpha (530-826 residues) was expressed in E. coli and purified by using conventional chromatography techniques.|
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