HIF1AN protein (30R-1240)

Purified recombinant Human HIF1AN protein

Synonyms HIFAN 1, FIH 1 protein, DKFZp762F1811 protein, Hypoxia-inducible factor 1 protein, HIFAN-1, Hypoxia-inducible factor asparagine hydroxylase protein, Hypoxia inducible factor 1 alpha subunit inhibitor protein, alpha subunit inhibitor Hypoxia inducible factor asparagine hydroxylase protein, Factor inhibiting HIF1 protein, Peptide aspartate beta dioxygenase protein, HIFAN-1 protein, HIFAN 1 protein, FLJ22027 protein, FLJ20615 protein, Hypoxia inducible factor 1 alpha inhibitor protein, FIH1 protein, Factor inhibiting HIF-1 protein, Hypoxia-Inducible Factor-1 Alpha Inhibitor, HIF1AN
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of HIF1AN protein (30R-1240)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-349 amino acids: MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKRCILFP PDQFECLYPY PVHHPCDRQS QVDFDNPDYE RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQEVGPLL NTMIKGRYN
Expression System E.coli
Grade & Purity > 90% pure
Molecular Weight 40.2 kDa (349 aa), confirmed by MALDI-TOF.
Form & Buffer Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0.
Concentration 1 mg/ml

Storage & Safety

Storage Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Hypoxia-inducible factor 1, alpha subunit inhibitor (HIF1AN), a member of the Fe2+ and 2-oxoglutarate-dependent dioxygenase superfamily, is a protein that hydoxylates a specific asparagine residue (Asn-803) within the HIF1alpha C-terminal transactivation domain. In normoxia, the HIF1AN-mediated hydroxylation of the HIF1alpha transactivation domain results in blockage of the HIF1alpha-p300/CBP interaction and represses transcriptional activity of HIF1alpha-targeted genes. Recombinant human HIF1AN protein was expressed in E. coli and purified by using conventional chromatography techniques.

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Images

  • Coomassie Blue stained SDS-PAGE of HIF1AN protein (30R-1240) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: €169.35
Size: 100 ug
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