Monoclonal REV (HIV-1 HxB2, HxB3) antibody, HIV-1, HIV1, HIV 1, HIV-1 antibody, HIV 1 antibody, HxB3) antibody, Anti REV (HIV-1 HxB2
Specificity
HIV1
Applications
ELISA, WB
Immunogen
HIV1, HxB2, HxB3 Rev antibody was raised in mouse using purified, full length rev (HIV-1 HxB2, HxB3) produced in E.coli Expression system as the immunogen.
Assay Information
Binds to recombinant rev (HIV-1 HxB2, HxB3) in ELISA and Western Blot. The antibody is epitope mapped to rev (70-84)
Store lyophilized product at 2-8 deg C short term, following reconstitution, aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles
Biohazard Information
Not tested for sterility or endotoxin content.
General Information
Biological Significance
Rev is a HIV gene. The name rev stands for "Regulator of Virion". The gene's protein product allows fragments of HIV mRNA that contain a Rev Response Element (RRE) to be exported from the nucleus to the cytoplasm. In the absence of the rev gene, the host RNA splicing machinery in the nucleus quickly splices the RNA so that only the smaller, regulatory proteins can be produced; in the presence of rev, RNA is exported from the nucleus before it can be spliced, so that the structural proteins and RNA genome can be produced.