HIV1 Nef antibody (FITC) (61-001203)

Mouse monoclonal HIV1 Nef antibody (FITC)

Synonyms Monoclonal HIV1 Nef antibody, Anti-HIV1 Nef antibody, HIV-1 Nef antibody, Nef antibody, C terminal core protein antibody, HIV nef -1 antibody, VAN antibody , Negative factor antibody, HIV nef -1, ABIN1 antibody, HIV1 nef, p27 antibody, 3'ORF antibody, F protein antibody, HIV nef 1, ABIN antibody, HIV nef 1 antibody
Specificity HIV-1 nef
Cross Reactivity Reacts with recombinant nef in ELISA and WB.
Applications ELISA, WB
Immunogen HIV1 Nef antibody (FITC) was raised using purified recombinant nef (HIV-1) produced in E.coli expression system as the immunogen.

Specifications

Host Mouse
Clone 2H12 N-terminus
Isotype IgG1
Grade & Purity > 95% pure
Tag/Conjugate FITC
Form & Buffer Supplied lyophilized in PBS buffer.
Concentration 50 ug per vial

Usage & Assay Information

Usage Recommendations ELISA: 1:1,000, WB: 1:1,000

Storage & Safety

Storage Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles

General Information

Biological Significance Nef is a early protein that may play a role in optimizing the host cell environment for viral replication without causing apoptosis. Nef enhances virus infectivity and pathogenicity. It down regulates surface MHC I molecules and internalized molecules are sequestered to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.

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Availability: In stock

Price: €294.49
Size: 50 ug
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