HIV1 Nef antibody (FITC) (61-001203)
Mouse monoclonal HIV1 Nef antibody (FITC)
Overview
Overview
| Synonyms | Monoclonal HIV1 Nef antibody, Anti-HIV1 Nef antibody, HIV-1 Nef antibody, Nef antibody, C terminal core protein antibody, HIV nef -1 antibody, VAN antibody , Negative factor antibody, HIV nef -1, ABIN1 antibody, HIV1 nef, p27 antibody, 3'ORF antibody, F protein antibody, HIV nef 1, ABIN antibody, HIV nef 1 antibody |
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| Specificity | HIV-1 nef |
| Cross Reactivity | Reacts with recombinant nef in ELISA and WB. |
| Applications | ELISA, WB |
| Immunogen | HIV1 Nef antibody (FITC) was raised using purified recombinant nef (HIV-1) produced in E.coli expression system as the immunogen. |
Specifications
| Host | Mouse |
|---|---|
| Clone | 2H12 N-terminus |
| Isotype | IgG1 |
| Grade & Purity | > 95% pure |
| Tag/Conjugate | FITC |
| Form & Buffer | Supplied lyophilized in PBS buffer. |
| Concentration | 50 ug per vial |
Usage & Assay Information
| Usage Recommendations | ELISA: 1:1,000, WB: 1:1,000 |
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Storage & Safety
| Storage | Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles |
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General Information
| Biological Significance | Nef is a early protein that may play a role in optimizing the host cell environment for viral replication without causing apoptosis. Nef enhances virus infectivity and pathogenicity. It down regulates surface MHC I molecules and internalized molecules are sequestered to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. |
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