HIV1p27Kip1 antibody (20R-PR002)

Rabbit polyclonal HIV1p27Kip1 antibody

Synonyms Polyclonal HIV1p27Kip1 antibody, Anti-HIV1p27Kip1 antibody, HIV1 p27 Kip1 antibody, HIVp27Kip -1 antibody, HIV1-p27-Kip1 antibody, HIVp27Kip -1, HIVp27Kip 1 antibody, HIVp27Kip 1, HIV1p27Kip1
Specificity Human
Cross Reactivity Mouse, rat
Applications IHC-F, IHC-P
Immunogen HIV1p27Kip1 antibody was raised in rabbit using a synthetic peptide derived from C terminal of human p27KIP1 as the immunogen.

Specifications

Host Rabbit
Isotype IgG1
Molecular Weight 27 kDa (predicted detection band MW)
Form & Buffer Protein A purified antibody supplied in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3.
Concentration 0.2 mg/ml

Usage & Assay Information

Usage Recommendations IHC-F: 1:100, IHC-P: 1:100

Storage & Safety

Storage Store at 4 deg C.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance The p27Kip1 gene has a DNA sequence similar to other members of the "Cip/Kip" family which include the p21Cip1/Waf1 and p57Kip2 genes. In addition to this structural similarity the "Cip/Kip" proteins share the functional characteristic of being able to bind several different classes of Cyclin and Cdk molecules. p27Kip1 binds to cyclin D either alone, or when complexed to its catalytic subunit CDK4. In doing so p27Kip1 inhibits the catalytic activity of CDK4, which means that it prevents CDK4 from adding phosphate residues to its principal substrate, the retinoblastoma (pRb) protein.

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Availability: In stock

Price: €119.83
Size: 100 ug
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