HLA MHC Class I antibody (10R-6691)

Mouse monoclonal HLA MHC Class I antibody

Synonyms Monoclonal HLA MHC Class I antibody, Anti-HLA MHC Class I antibody, MHCI antibody
Specificity Human
Applications Functional Assay
Assay Information The ED50, as determined by a mouse splenocyte survival assay, is 1.6 ug/ml.

Images

Flow Cytometric analysis using HLA MHC Class I antibody (10R-6691)

Staining of normal human peripheral blood mononuclear cells either unactivated (left) or 3-day PHA-activated (right) with 0.25 ug of Mouse IgG1 kappa Isotype Control (open histogram) or 0.25 ug of Anti-Human HLA- MHC Class I free chain without beta 2 microglobulin Purified (filled histogram) followed by F (ab'')2 Anti-Mouse IgG (PE). Total viable cells were used for analysis.

Specifications

Host Mouse
Clone A4
Isotype IgG1
Method of Purification HLA MHC Class I antibody was purified by affinity chromatography.
Form & Buffer Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration 100 ug/ml

Storage & Safety

Storage Store at 2-8 deg C. Do not freeze. Protect from light.

General Information

Biological Significance The A4 monoclonal antibody reacts with the class I human leukocyte antigen complex in the absence of beta2 microglobulin. There are three class I alpha-chain genes in humans, called HLA-A, -B and -C. Normally, HLA class I proteins are associated non-covalently with beta2 microglobulin. The function of the HLA class I complex is to present peptides derived from intracellular pathogens, including viral pathogens, on the cell surface to antigen specific CD8+ cytotoxic T cells. Class I HLA is expressed by the majority of nucleated cells.

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Images

  • Flow Cytometric analysis using HLA MHC Class I antibody (10R-6691) | Staining of normal human peripheral blood mononuclear cells either unactivated (left) or 3-day PHA-activated (right) with 0.25 ug of Mouse IgG1 kappa Isotype Control (open histogram) or 0.25 ug of Anti-Human HLA- MHC Class I free chain without beta 2 microglobulin Purified (filled histogram) followed by F (ab'')2 Anti-Mouse IgG (PE). Total viable cells were used for analysis.

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Price: €262.58

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Price: €262.58
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