HMGA1 protein (His tag) (80R-1896)
Purified recombinant HMGA1 protein
|Synonyms||HMGA1, HMGA-1 protein, HMG-R protein, HMGA-1, HMGA1A protein, HMGA 1 protein, HMGA 1, HMGIY protein|
Coomassie Blue stained SDS-PAGE of HMGA1 protein (His tag) (80R-1896)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-107 amino acids: MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQLEH HHHHH|
|Grade & Purity||> 90% pure|
|Molecular Weight||12.7 kDa (115aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 50% glycerol and 0.2M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||High mobility group protein HMG-I/HMG-Y, also known as HMGA1, is a member of the non-histone chromosomal high mobility group protein (HMG) family. HMGA1 consists of a highly conserved AT-hook DNA-binding domain that mediates binding to AT-rich sequences in the minor groove of chromosomal DNA. It functions as an architectural chromatin-binding transcription factor altering the conformation of DNA by modulating nuclear protein-DNA complexes. It is involved in many cellular processes including growth regulation, viral induction of beta-IFN gene and regulation of inducible gene transcription. Recombinant human HMGA1 protein, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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