HRAS protein (His tag) (80R-1283)
Purified recombinant Human HRAS protein
|Synonyms||GC104230 protein, v-Ha-ras Harvey rat sarcoma viral oncogene homolog C BAS/HAS protein, CTLO protein, HRAS1 protein, c H ras protein, K ras protein, HAMSV protein, H RASIDX protein, c ras Ki 2 activated oncogene protein, H Ras 1 protein, RASH1 protein, Ras family small GTP binding protein H Ras protein, vHa RAS., Transformation gene oncogene HAMSV protein, Ha Ras protein, HRAS protein, p19 H RasIDX protein protein, p21ras protein, Transforming protein p21 protein, HMG14 protein, C HA RAS1 protein, N ras protein, c has/bas p21 protein protein, v Ha ras Harvey rat sarcoma viral oncogene homolog protein, GTP and GDP binding peptide B protein, VH Ras protein, Ha Ras1 proto oncoprotein protein|
Coomassie Blue stained SDS-PAGE of HRAS protein (His tag) (80R-1283)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-186 amino acids: MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI KRVKDSDDVP MVLVGNKCDL AARTVESRQA QDLARSYGIP YIETSAKTRQ GVEDAFYTLV REIRQHKLRK LNPPDESGPG CMSCKCLEHH HHHH|
|Grade & Purity||> 90% pure|
|Molecular Weight||22.0 kDa (194aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||HRAS, also known as GTPase HRas, belongs to the Ras family which function in signal transduction pathways. This protein can bind GTP and GDP, and it has intrinsic GTPase activity. HRAS undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. Defects in HRAS are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Recombinant human HRAS protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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