HSD17B10 protein (His tag) (80R-1285)
Purified recombinant Human HSD17B10 protein
|Synonyms||Hydroxyacyl CoA Dehydrogenase type II protein, ER associated amyloid beta-binding protein protein, SCHAD protein, HSD17B10 protein, Type II HADH protein, Type 10 17beta hydroxysteroid dehydrogenase protein, HSD17B10, Amyloid beta binding polypeptide protein, SDR5C1 protein, HADH2 protein, ERAB protein, Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase protein, MRPP2 protein, MHBD protein, Mitochondrial ribonuclease P protein 2 protein, Hydroxyacyl Coenzyme A dehydrogenase type II protein, 3 hydroxyacyl CoA dehydrogenase type II protein, XH98G2 protein, HSDB10 17, MRX17 protein, 3 hydroxyacyl CoA dehydrogenase type 2 protein, ABAD protein, Amyloid beta peptide binding alcohol dehydrogenase protein, 17 beta hydroxysteroid dehydrogenase 10 protein, Mitochondrial RNase P protein 2 protein, HCD 2 protein, Short chain type dehydrogenase/reductase XH98G2 protein, CAMR protein, Mental retardation X linked syndromic 11 protein, Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 protein, Ads9 protein, AB binding alcohol dehydrogenase protein, HADH 2 protein, 17 beta hydroxysteroid dehydrogenase type 10 protein, HSDB10-17, Short chain dehydrogenase/reductase family 5C member 1 protein, 3 hydroxy 2 methylbutyryl CoA dehydrogenase protein, Endoplasmic Reticulum Amyloid Binding Protein protein, Endoplasmic reticulum associated amyloid beta peptide binding protein protein, HCD2 protein, Hydroxysteroid (17 beta) dehydrogenase 10 protein, HSDB10 17 protein, HSDB10-17 protein, Type 10 17b HSD protein, Amyloid beta peptide binding protein protein, 3-hydroxyacyl-CoA dehydrogenase type-2, DUPXp11.22 protein, 17b HSD10 protein|
Coomassie Blue stained SDS-PAGE of HSD17B10 protein (His tag) (80R-1285)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||12-261 amino acids: MGSSHHHHHH SSGLVPRGSH MVAVITGGAS GLGLATAERL VGQGASAVLL DLPNSGGEAQ AKKLGNNCVF APADVTSEKD VQTALALAKG KFGRVDVAVN CAGIAVASKT YNLKKGQTHT LEDFQRVLDV NLMGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL PIARDLAPIG IRVMTIAPGL FGTPLLTSLP EKVCNFLASQ VPFPSRLGDP AEYAHLVQAI IENPFLNGEV IRLDGAIRMQ P|
|Grade & Purity||> 95% pure|
|Molecular Weight||28.1 kDa (271aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 1mM DTT, and 100mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||HSD17B10 is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. HSD17B10 plays an important role in processing steroid hormones and fats, and also helps break down the protein building block (amino acid) isoleucine. This enzyme is also necessary for several chemical reactions involving female sex hormones (estrogens) and male sex hormones (androgens). It is essential for maintaining appropriate levels of male and female sex hormones. This protein may contribute to the neuronal dysfunction associated with Alzheimer disease. Recombinant HSD17B10 protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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