HSF1 protein (His tag) (80R-1054)
Purified recombinant Human HSF1 protein
Overview
Overview
| Synonyms | HSF 1 protein, HSTF 1., HSF-1, HSF1 protein, HSF 1, Heat shock factor 1 protein, HSF-1 protein, Heat shock transcription factor 1 protein, Heat shock transcription factor 1(HSTF) protein, HSF1, Heat shock factor 1 Heat shock factor protein 1 protein |
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| Species | Human |
| Protein Type | Recombinant |
| Applications | SDS-PAGE |
Images
Coomassie Blue stained SDS-PAGE of HSF1 protein (His tag) (80R-1054)
Figure annotation denotes ug of protein loaded and % gel used.
Specifications
| Residues | 1-529 amino acids: MGSSHHHHHH SSGLVPRGSH MDLPVGPGAA GPSNVPAFLT KLWTLVSDPD TDALICWSPS GNSFHVFDQG QFAKEVLPKY FKHNNMASFV RQLNMYGFRK VVHIEQGGLV KPERDDTEFQ HPCFLRGQEQ LLENIKRKVT SVSTLKSEDI KIRQDSVTKL LTDVQLMKGK QECMDSKLLA MKHENEALWR EVASLRQKHA QQQKVVNKLI QFLISLVQSN RILGVKRKIP LMLNDSGSAH SMPKYSRQFS LEHVHGSGPY SAPSPAYSSS SLYAPDAVAS SGPIISDITE LAPASPMASP GGSIDERPLS SSPLVRVKEE PPSPPQSPRV EEASPGRPSS VDTLLSPTAL IDSILRESEP APASVTALTD ARGHTDTEGR PPSPPPTSTP EKCLSVACLD KNELSDHLDA MDSNLDNLQT MLSSHGFSVD TSALLDLFSP SVTVPDMSLP DLDSSLASIQ ELLSPQEPPR PPEAENSSPD SGKQLVHYTA QPLFLLDPGS VDTGSNDLPV LFELGEGSYF SEGDGFAEDP TISLLTGSEP PKAKDPTVS |
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| Expression System | E.coli |
| Grade & Purity | > 75% pure |
| Molecular Weight | 59.4 kDa (549aa) |
| Tag/Conjugate | His tag |
| Form & Buffer | Supplied as a liquid in 20mM Tris, pH 8.0, containnig 50mM NaCl, and 1mM DTT. |
| Concentration | 1 mg/ml |
Storage & Safety
| Storage | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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General Information
| Biological Significance | Heat shock factor 1 (HSF1) is a major transactivator of heat shock proteins in response to environmental changes, and it is also involved in oogenesis, spermatogenesis, and placental development. Best known for its involvement in heat shock response, Hsf1p regulates the transcription of hundreds of targets, including genes involved in protein folding, detoxification, energy generation, carbohydrate metabolism, and cell wall organization. Recombinant HSF1, fused to His tag, was expressed in E. coli and purified by using conventional chromatography techniques. |
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