Hsp90 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human HSP90 , identical to the related Rabbit and rat sequence as the immunogen
Immunohistochemical staining using Hsp90 antibody (70R-13881)
Immunohistochemistry of paraffin-embedded section of Human Mammary Cancer Tissue
Hsp90 antibody
Immunohistochemical staining using Hsp90 antibody (70R-13881)
Immunohistochemistry of paraffin-embedded section of Human Mammary Cancer Tissue
Western Blot analysis using Hsp90 antibody (70R-13881)
Lane 1: Rat Testicle Tissue Lysate; Lane 2: CCRF-CEM Cell Lysate; Lane 3: Hela Cell Lysate; Lane 4: SMMC Cell Lysate; Lane 5: HT1080 Cell Lysate; Lane 6: Colo320 Cell Lysate
Specifications
Host
Rabbit
Isotype
IgG
Method of Purification
Hsp90 antibody was purified by affinity chromatography
Optimal conditions to be determined by the end user
Storage & Safety
Storage
Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.
General Information
Biological Significance
Heat shock proteins (HSPs) are ubiquitously expressed in all organisms. A major function of Hsp90 and other HSPs is to act as molecular chaperones. Hsp90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand bound receptor transcriptionally inactive. Hsp90 binds the GR as a heterocomplex composed of either Hsp56 or cyclophilin 40, forming an aporeceptor complex. Hsp0 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an aporeceptor complex with estrogen and androgen receptors.