HSV2 protein (30-1871)
Purified Native HSV2 protein
Overview
Overview
| Synonyms | HSV2 antigen, Herpes simplex virus 2 proetin, Herpes simplex virus protein, Human herpesvirus 2 protein, Herpesvirus 2 protein, HHV-2 protein, HHV 2 protein |
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| Species | Viral |
| Protein Type | Native |
Specifications
| Source | HSV2 particles from cell lysate |
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| Grade & Purity | > 80% pure |
| Form & Buffer | Supplied in PBS, pH 7.4 + 0.1% triton x-100 |
| Concentration | 0.6-1.2 mg/ml |
Storage & Safety
| Storage | Store at -80 deg C |
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General Information
| Product Use | HSV2 protein for use in the research laboratory |
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| Biological Significance | HSV2 is considered to be genital herpes, in which one in five people are correctly diagnosed. An estimated 45 million (one out of four) Americans are infected with the virus. The virus is transmitted mostly by sexual contact. |
| Implications in Disease | Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with a scab characteristic of herpetic disease. Sometimes, the viruses cause very mild or atypical symptoms during outbreaks. However, as neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks. In an outbreak, the virus in a nerve cell becomes active and is transported via the neuron's axon to the skin, where virus replication and shedding occur and cause new sores. It is one of the most common sexually transmitted infections. In the presence of a certain gene variation (APOE-epsilon4 allele carriers), a possible link between HSV-1 and Alzheimer's disease was reported in 1979. |
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